We see Columbus, Tallahassee, Wichita and Little Rock a decade after the events of the first film. There is a fight between Wichita and Columbus that causes a serious problem between the members of the group. Despite of that they need to move from the White House to the heartland of America. On their way, the four slayers come across a new kind of evolved zombies which forces them to create new strategies and ways to outsmart the disgusting creatures. There must be a way to win, since the group also meets human survivors. One of them is Nevada, a great new zombie hunter. Now the show begins and while killing zombies, Columbus, Tallahassee, Wichita and Little Rock need also to find a way and deal with the problems in their own extraordinary family.